The use of any hallucinogen (and too a lesser degree, pot) involves "set," i.e. mind-set, mood, emotional state and "setting," the environment and/ or people with whom one is tripping at the time. The combination of set and setting in conjunction with the effects of the drug produce the kind of trip one has, good or bad. People do experience psychotic breaks from reality in a bad trip and this can be extremely traumatic with long-term and lingering after effects. A good trip can be very euphoric and transcendent in comparison. Which you'll get is again, dependent on set, setting, the drug and certain amount of luck and randomness. Messing with your neurotransmitters at this profound level should not be undertaking lightly, if at all.